ARA-290

Non-erythropoietic EPO-derived peptide for nerve repair and inflammation.

ARA-290 is primarily studied for its role in protecting nerve tissue, modulating inflammation, and supporting cellular repair. It has shown potential in preclinical and early clinical research for applications involving neuropathic pain, metabolic dysfunction, and tissue injury. Its mechanism centers on reducing pro-inflammatory cytokine activity and promoting restoration of damaged cells, particularly within the nervous system.

Neuropathic pain is dysfunction in the nervous system itself, not necessarily a product of an actual physical injury. This can show up as numbness, a burning sensation, pins and needles or an electric shock like phenomenon. Chronic pain like sciatica is but one example. ARA-290 was investigated for its role in disrupting these illusory pain signals.

ARA-290 is a synthetic peptide derived from a specific region of erythropoietin (EPO), engineered to selectively target the innate repair receptor (IRR) without stimulating red blood cell production. This design allows it to retain tissue-protective and anti-inflammatory signaling properties while avoiding the hematopoietic effects typically associated with EPO.

Key Features

• Selective activation of the innate repair receptor (IRR)
• Non-erythropoietic (does not increase red blood cell production)
• Investigated for neuroprotective and anti-inflammatory effects
• Short peptide structure with targeted biological activity

Research Areas of Interest

• Small fiber neuropathy and nerve repair
• Chronic inflammation and inflammatory signaling pathways
• Metabolic and mitochondrial function
• Tissue protection following injury or stress

ARA-290 is typically supplied as a lyophilized powder for research purposes and requires reconstitution prior to use. Due to its investigational status, it is not approved for general medical use and is intended strictly for laboratory and research applications.

Early clinical data suggests a dose of 2-6mg per day for 2-4 weeks.

ARA-290 · 10mg · For laboratory and research use only. Not for human or animal consumption. 18+ qualified researchers only.